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Conceptual schematic illustrating the attenuation of circadian rhythm amplitude and phase shifts in aging, with a particular emphasis on nocturnal melatonin decline as a central driver of sleep fragmentation, metabolic dysregulation, and reduced antioxidant capacity ( The figure highlights age-related changes in key physiological variables, including restactivity cycles, core body temperature, hormonal secretion (melatonin and cortisol), suprachiasmatic nucleus (SCN) neuronal activity, and metabolic indicators such as glucose regulation

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doi:10.1016/0014-5793(90)80922-6

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Peng, L., Verkhratsky, A., Gu, L